Argentina will welcome back wing Ramiro Moyano, but fellow winger Bautista Delguy was ruled out with a shoulder injury he picked up in the clash against the All Blacks.
The absence of Delguy has triggered a backline reshuffle with two personnel and two positional changes from the side beaten 35-17 by New Zealand in Buenos Aires.
Moyano comes in on the left wing and Matias Moroni switches from there to the right wing in place of Delguy.
Matias Orlando is promoted from the bench to outside centre, Jeronimo de la Fuente moves from outside to inside centre and Bautista Ezcurra drops out of the matchday 23.
There are two changes to the bench with utility back Santiago Gonzalez Iglesias and prop Santiago Garcia Botta called up in place of promoted Orlando and demoted Juan Pablo Zeiss.
If the Pumas win this match they will end third ahead of the Wallabies.
The embattled Australians have recalled flyhalf Bernard Foley and shifted Kurtley Beale to inside centre for their clash against the Pumas.
Foley started the first two matches against New Zealand, but was dropped in favour of Beale.
Matt Toomua moves to the bench to make place for Beale.
The rest of the team that played the Springboks last weekend remains the same.
So far Australia is experiencing a very poor season with six losses in eight matches. The loser of this match will get the wooden spoon for the 2018 Rugby Championship.
15 Emiliano Boffelli; 14 Matias Moroni, 13 Matias Orlando, 12 Jeronimo de la Fuente, 11 Ramiro Moyano; 10 Nicolas Sanchez, 9 Gonzalo Bertranou; 8 Javier Ortega Desio, 7 Marcos Kremer, 6 Pablo Matera; 5 Tomas Lavanini, 4 Guido Petti; 3 Ramiro Herrera, 2 Agustin Creevy (captain), 1Nahuel Tetaz Chaparro
Substitutes: 16 Julian Montoya, 17 Santiago Garcia Botta, 18 Santiago Medrano, 19 Matias Alemanno, 20 Juan Manuel Leguizamon, 21 Tomas Cubelli, 22 Santiago Gonzalez Iglesias, 23 Sebastian Cancelliere
Coach: Mario Ledesma (ARG)
15 Dane Haylett-Petty; 14 Israel Folau, 13 Reece Hodge, 12 Kurtley Beale, 11 Marika Koroibete; 10 Bernard Foley, 9 Will Genia; 8 David Pocock, 7 Michael Hooper (captain), 6 Ned Hanigan; 5 Adam Coleman, 4 Izack Rodda; 3 Taniela Tupou, 2 Folau Faingaa, 1 Scott Sio
Substitutes: (one to be omitted): 16 Tolu Latu, 17 Sekope Kepu, 18 Allan Alaalatoa, 19 Rob Simmons, 20 Rory Arnold, 21 Caleb Timu, 22 Nick Phipps, 23 Matt Toomua, 24 Tom Banks
Coach: Michael Cheika (AUS)
Written By Carl Coertzen – 05/10/18