Argentina and Australia will play each other in the Rugby Championship at Twickenham on 8 October.
The match marks the first in the history of the Rugby Championship to be played outside of the four core territories and is an opportunity for the Southern Hemisphere to return to London a year after filling the top four places at the Rugby World Cup.
“Playing again at Twickenham, which is one of the main stages of rugby in the world, is fantastic for the UAR,” said UAR president Carlos Araujo.
Rugby Football Union chief executive Ian Ritchie said he was “delighted” to welcome the two nations – who faced each other at Twickenham in the semi-finals of last year’s Rugby World Cup.
“We were treated to a great match between these two teams in the Rugby World Cup and I’m sure that it’s set to be another high octane encounter in the autumn,” added Ritchie.
Australian Rugby Union CEO Bill Pulver believes the match gives them a brilliant opportunity to showcase Southern Hemisphere rugby.
“Our recent broadcast agreement with Sky Sports also indicates there is huge interest in the tournament in the UK,” said Pulver.
“From an ARU perspective this is another fantastic opportunity to showcase the Qantas Wallabies to our fans based in England, as well as thousands of new fans.”