Northampton prop Paul Hill, Harlequins back-row Jack Clifford and Bath back Ollie Devoto could all make their England debuts in the Six Nations.
The players were retained by head coach Eddie Jones in a 23-man squad likely to stay the same to face Scotland at Murrayfield on 6 February.
Dylan Hartley will play at hooker after being named captain for the tournament.
Former skipper Chris Robshaw is expected to start at blindside flanker.
While James Haskell and Billy Vunipola could make up the rest of the back-row.
With Elliot Daly being released back to Wasps, Jonathan Joseph is set to start at outside centre, with Owen Farrell at inside centre and George Ford at fly-half.
Full England squad for game against Scotland:
Forwards: Dan Cole (Leicester), Jack Clifford, Joe Marler, Chris Robshaw (all Harlequins), Jamie George, George Kruis, Billy Vunipola, Mako Vunipola (Saracens), Dylan Hartley, Paul Hill, Courtney Lawes (Northampton), James Haskell, Joe Launchbury (Wasps).
Backs: Mike Brown, Danny Care (both Harlequins), Ollie Devoto, George Ford, Jonathan Joseph, Anthony Watson (Bath), Owen Farrell, Alex Goode (Saracens), Jack Nowell (Exeter), Ben Youngs (Leicester).