Northampton Saints prop Alex Corbisiero and Leicester Tigers lock Geoff Parling will miss England’s autumn internationals because of injury.
Corbisiero, 26, suffered a shoulder ligament tear during Northampton’s win over Bath on Saturday and is not expected to return until early 2015.
Parling, 30, will be out until December following a series of concussions.
England head coach Stuart Lancaster is already set to be without Mako Vunipola, Dan Cole and Tom Youngs.
Parling, who had to be withdrawn during Leicester’s 45-0 defeat by Bathon 20 September, has suffered five concussions in 11 months, with the injury against Mike Ford’s side the second in three matches.
He has been capped 21 times by England and played a part in all three of the British & Irish Lions’ Tests against Australia in 2013.
“Geoff saw the relevant specialist this week and will have time out of the game now,” said Tigers director of rugby Richard Cockerill. “He’ll probably have three or four weeks of complete down time and then he’ll be reintegrated into training.
“You’d like to think that by December he’ll be playing again. And there’s no doubt about that, he will play again. There are no issues over that.”
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